|
|
(S)-2-amino-6-oxohexanoate + NADP+ + H2O <=> L-2-aminoadipate + NADPH + H+
|
1.2.1.31
L-aminoadipate-semialdehyde dehydrogenase
|
–
|
BMK
|
|
BRENDA:
BR29399
KEGG:
R03103
MetaCyc:
1.2.1.31-RXN
SABIO-RK:
2941
|
|
|
|
(S)-2-amino-6-oxohexanoate + NAD+ + H2O <=> L-2-aminoadipate + NADH + H+
|
1.2.1.31
L-aminoadipate-semialdehyde dehydrogenase
|
–
|
K
|
|
BRENDA:
BR29399-a
KEGG:
R03102
MetaCyc:
1.2.1.31-RXN_WOP;
ALLYSINE-DEHYDROG-RXN
SABIO-RK:
6517
|
|
|
|
L-2-aminoadipate + L-cysteine + L-valine + ATP + H2O <=> H+ + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
MK
|
|
BRENDA:
BR40508
KEGG:
R04870
MetaCyc:
6.3.2.26-RXN
|
|
|
|
phenylacetyl-CoA + isopenicillin_N + H2O <=> CoA + penicillin_G + L-2-aminoadipate + H+
|
2.3.1.164
isopenicillin-N N-acyltransferase
|
–
|
|
|
BRENDA:
BR40564
KEGG:
R04868
MetaCyc:
2.3.1.164-RXN
|
|
|
|
L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate
|
2.6.1.39
2-aminoadipate transaminase
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
–
|
BMK
|
|
BRENDA:
BR47689
KEGG:
R01939
MetaCyc:
2-AMINOADIPATE-AMINOTRANSFERASE-RXN
SABIO-RK:
1992
|
|
|
|
(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP+ <=> L-2-aminoadipate + ATP + NADPH + H+
|
1.2.1.95
L-2-aminoadipate reductase
|
–
|
K
|
|
BRENDA:
BR51342
KEGG:
R11679
MetaCyc:
RXN-16756
|
|
|
|
DELTA1-piperidine_6-carboxylate + NAD+ + H2O <=> L-2-aminoadipate + NADH + H+
|
1.2.1.31
L-aminoadipate-semialdehyde dehydrogenase
|
–
|
BM
|
|
BRENDA:
BS189205;
BS451452
KEGG:
R11231
MetaCyc:
RXN-10855_WOP;
RXN-8162
|
|
|
|
ATP + [LysW]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate
|
6.3.2.43
[amino-group carrier protein]---L-2-aminoadipate ligase
|
–
|
K
|
|
BRENDA:
BS424678
KEGG:
R09775
|
|
|
|
DELTA1-piperidine_6-carboxylate + NADP+ + H2O <=> L-2-aminoadipate + NADPH + H+
|
1.2.1.31
L-aminoadipate-semialdehyde dehydrogenase
|
–
|
M
|
|
KEGG:
R11232
MetaCyc:
RXN-10855
|
|
|
|
L-2-aminoadipate + ATP <=> L-2-aminoadipate_adenylate + diphosphate
|
1.2.1.95
L-2-aminoadipate reductase
|
–
|
K
|
|
KEGG:
R03098
SABIO-RK:
2938
|
|
|
|
isopenicillin_N + acyl-CoA + H2O <=> penicillin + CoA + L-2-aminoadipate
|
2.3.1.164
isopenicillin-N N-acyltransferase
|
–
|
K
|
|
KEGG:
R06361
|
|
|
|
L-2-aminoadipate + [amino_group_carrier_protein]-C-terminal-L-glutamate + ATP <=> [amino-group_carrier_protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] + ADP + phosphate + H+
|
6.3.2.43
[amino-group carrier protein]---L-2-aminoadipate ligase
|
–
|
M
|
|
MetaCyc:
RXN-15002
|
|
|
|
ATP + L-2-aminoadipate + holo-[LYS2_L-2-aminoadipyl-carrier-protein] <=> AMP + diphosphate + L-2-aminoadipyl-[LYS2_L-2-aminoadipyl-carrier-protein]
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-16757
|
|
|
|
isopenicillin_N + H2O <=> 6-aminopenicillanic_acid + L-2-aminoadipate
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-17061
|
|
|
|
L-2-aminoadipate + acetyl-CoA <=> H+ + N2-acetyl-L-aminoadipate + CoA
|
2.3.1
|
–
|
|
|
MetaCyc:
RXN-5181
|
|
|
|
octanoyl-CoA + isopenicillin_N + H2O <=> H+ + CoA + penicillin_K + L-2-aminoadipate
|
2.3.1.164
isopenicillin-N N-acyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-8809
|
|
|
|
acetyl-CoA + L-2-aminoadipate <=> CoA + 2-acetylaminohexanedioate
|
2.3.1.1
amino-acid N-acetyltransferase
|
–
|
|
|
BRENDA:
BS320235
|
|
|
|
L-2-aminoadipate <=> D-2-Aminoadipic_acid
|
5.1.1.3
glutamate racemase
|
–
|
|
|
BRENDA:
BS407244
|
|
|
|
L-2-aminoadipate + 4-hydroxyphenylpyruvate <=> 2-oxoadipate + L-tyrosine
|
2.6.1.39
2-aminoadipate transaminase
|
–
|
|
|
BRENDA:
BS423709
|
|
|
|
phenoxyacetyl-CoA + isopenicillin_N + H2O <=> CoA + Penicillin_V + L-2-aminoadipate
|
2.3.1.164
isopenicillin-N N-acyltransferase
|
–
|
|
|
BRENDA:
BS421200
|
|
|
|
2-oxoadipate + NADPH + NH3 <=> L-2-aminoadipate + NADP+ + H2O
|
1.4.1.4
glutamate dehydrogenase (NADP+)
|
–
|
|
|
BRENDA:
BS371741
|
|
|
|
ATP + an_[amino_group_carrier_protein]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + an_[amino_group_carrier_protein]-C-terminal-N-(1,5-dicarboxypentan-1-yl)-L-glutamine
|
6.3.2.43
[amino-group carrier protein]---L-2-aminoadipate ligase
|
–
|
B
|
|
BRENDA:
BR50906
|
|
|
|
3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-2-aminoadipate <=> L-Histidinol_phosphate + 2-oxoadipate
|
2.6.1.9
histidinol-phosphate transaminase
|
–
|
|
|
BRENDA:
BS354113
|
|
|
|
L-2-aminoadipate + L-cystathionine + L-valine + ATP <=> N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289205
|
|
|
|
L-2-aminoadipate + L-cysteine + L-valine + ATP <=> N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289195
|
|
|
|
DL-valine + O-methylserine + L-2-aminoadipate + ATP <=> L-O-(methylserinyl)-D-valine + L-O-(methylserinyl)-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289200
|
|
|
|
L-2-aminoadipyl-[LYS2_peptidyl-carrier-protein] + AMP + diphosphate <=> L-2-aminoadipate + holo-[LYS2_peptidyl-carrier-protein] + ATP
|
1.2.1.95
L-2-aminoadipate reductase
|
–
|
|
|
BRENDA:
BR51343
|
|
|
|
L-2-aminoadipate + allylglycine + L-valine + ATP <=> L-delta-(aminoadipyl)-L-allylglycinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289197
|
|
|
|
L-2-aminoadipate + L-cysteine + L-allo-isoleucine + ATP <=> L-delta-(aminoadipyl)-L-cysteinyl-D-allo-isoleucine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289199
|
|
|
|
L-2-aminoadipate + L-cysteine + L-isoleucine + ATP <=> L-delta-(aminoadipyl)-L-cysteinyl-D-allo-isoleucine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289202
|
|
|
|
L-2-aminoadipate + L-Vinylglycine + L-valine + ATP <=> L-delta-(aminoadipyl)-L-vinylglycinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289198
|
|
|
|
L-2-aminoadipate + L-homocysteine + L-valine + ATP <=> N-(5-amino-5-carboxypentanoyl)-L-homocysteinyl-D-valine + AMP + diphosphate
|
6.3.2.26
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
|
–
|
|
|
BRENDA:
BS289203
|
|
|
|
L-glutamine + 2-oxoadipate <=> 2-Oxoglutaramate + L-2-aminoadipate
|
2.6.1.50
glutamine---scyllo-inositol transaminase
|
–
|
|
|
BRENDA:
BS356697
|
|
|
|
L-phenylalanine + 2-oxoadipate <=> phenylpyruvate + L-2-aminoadipate
|
2.6.1.57
aromatic-amino-acid transaminase
|
–
|
|
|
BRENDA:
BS437645
|
|
|
|
3-hydroxykynurenine + 2-oxoadipate <=> 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-2-aminoadipate
|
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
|
|
|
SABIO-RK:
12046
|
|
|
|
2-oxoadipate + L-kynurenine <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-2-aminoadipate
|
2.6.1.7
kynurenine---oxoglutarate transaminase
|
–
|
|
|
SABIO-RK:
12043
|
|
|
|
glyoxylate + L-2-aminoadipate <=> glycine + 2-oxoadipate
|
2.6.1.39
2-aminoadipate transaminase
|
–
|
|
|
SABIO-RK:
13947
|
|